Special Report

Published on 24 March 2026

Budget impact analysis of implementation of biosimilars in a private health insurance company of large size in Southern Brazil 

Study objectives: To evaluate the budget impact of implementing a physician-led biosimilar switching programme within a large private health insurance company in Southern Brazil. Methods: This retrospective observational study analysed real-world data from a private payer perspective over 24 months (November 2022–October 2024). Six biologicals were included: infliximab, adalimumab, etanercept, rituximab, trastuzumab, and bevacizumab. In year…

Author(s): Rafael Gama, MD, MBA, Associate Professor Valderilio Feijó Azevedo, MSc, MD, PhD, Paula Heberle, MBA, Sergio Mauricio Menoncin, MSc, Daniela Toigo, MBA, Fabiana Aguiar, PG, Josymar Nascimento Júnior, MD, Ana Carolina Maciel, PG, Ricardo Luiz Pereira Bueno, BA, MHA, PhD

DOI: 10.5639/gabij.2026.1501.005

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Original Research

Published on 23 March 2026

Real-world evaluation of dosing and haemoglobin A1c (HbA1c) in patients converted from insulin glargine (Lantus®) to insulin glargine (Basaglar®) in Saudi Arabia 

Introduction/Study objective: About 28% of Saudi Arabia population above 15 years old are diagnosed with diabetes. Basal insulin glargine Lantus and its’ biosimilar Basaglar, are long-acting insulin that regulate blood glucose levels over 24 hours. Patients switch between basal insulins for various reasons including adverse events, availability and cost. Switching should be done with careful…

Author(s): Salwa Almomen, MD, MSc, Fares Alrubaish, PharmD, Radwan Hafiz, PharmD, Ali M Alhomaidan, PhD

biosimilars, HbA1c, interchangeability, long-acting insulin analogues, switching, treatment conversion

DOI: 10.5639/gabij.2026.1501.003

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Editor's Letter

Published on 10 April 2025

Editor’s introduction to the initial issue of the 14th volume of GaBI Journal

In this first issue of 2025, we have some controversial criticism of an article previously published in GaBI Journal [1}, as well as a paper on pricing of biosimilars/biologicals after patent expiry and a meeting report on claimed weakening of FDA regulatory standards for biosimilars and its perceived effects on undermining physician confidence in biosimilar…

Author(s): Robin Thorpe, PhD, FRCPath

DOI: 10.5639/gabij.2025.1401.001

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Editor's Letter

Published on 10 August 2025

A spectrum of generics and biosimilars: research, reports, and interviews

In this second issue of 2025, we have a diverse spectrum of publications which include one original research paper in the generics area and biosimilar-focused articles which comprise one special report, one meeting report, one interview and one sponsored article.  The first article in this issue is an Original Research paper titled ‘Therapeutic equivalence of…

Author(s): Robin Thorpe, PhD, FRCPath

DOI: 10.5639/gabij.2025.1402.006

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Review Article

Published on 04 May 2026

Bridging the global health equity gap: the impact of local biological manufacturing on patient access in Iran

Introduction/Study Objectives: Biological therapies have revolutionized the treatment of cancers, autoimmune, and metabolic diseases. However, access to these life-saving treatments remains severely limited in low- and middle-income countries due to high costs and infrastructure deficits. This study evaluates the impact of local manufacturing of biosimilars and complex biologicals on patient access in Iran, a lower-middle-income…

Author(s): Soheil Roshanzamiri, PharmD, Deyhim Atarod, PhD, Elmira Sayari, PharmD

access to medicines, biopharmaceutical manufacturing, biosimilars, health gain, Iran, pharmacoeconomics

DOI: 10.5639/gabij.2026.1502.

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Table Contents

Published on 15 April 2024

2024/1 GaBI Journal Table of Contents

Editor’s Letter First 2024 GaBI Journal issue highlights Original Research Budget impact analysis of a rituximab intravenous biosimilar in patients with follicular lymphoma and large B-cell non-Hodgkin lymphoma in Chile Pharmacokinetic bioequivalence studies of a new Etoricoxib tablet formulation developed using proprietary MiST technology — risk assessment and mitigation using GastroPlus software Perspective Comparative efficacy…

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Special Report

Published on 18 May 2026

Economic feasibility of ‘Pay One Price’: an analysis of three biosimilar molecules with different prices and indicated for rheumatoid arthritis in a medium size HMO 

Introduction/Objective: To evaluate the economic feasibility of a uniform ‘Pay One Price’ (POP) pricing model for three tumour necrosis factor (TNF) inhibitor biosimilars (adalimumab, infliximab, etanercept) used in rheumatoid arthritis (RA) treatment within a Brazilian medium-sized health maintenance organization (HMO). Methods: Medication prices were obtained from Brazil’s Chamber for the Regulation of the Medicines Market (CMED).…

Author(s): Francisco Eduardo Prota, MD, PhD, Ricardo Luiz Pereira Bueno, BA, MHA, PhD, Nanci Utida, MD

biosimilars, Brazil, budget impact analysis, Pay One Price, rheumatoid arthritis, TNF-α inhibitor

DOI: 10.5639/gabij.2026.1502.

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Editor's Letter

Published on 10 April 2026

Bridging generics and biosimilars: new evidence, real-world impact, and regulatory debate to start Volume 15

In this first issue of 2026 (Volume 15), we feature two original research manuscripts—one in the generics field and the other on biosimilars—alongside one opinion and one special report, both of which address biosimilar topics.  The first Original Research, titled ‘A bioequivalence study of paliperidone palmitate once-monthly (156 mg/mL) extended-release injectable in patients with schizophrenia’,…

Author(s): Robin Thorpe, PhD, FRCPath

DOI: 10.5639/gabij.2026.1501.001

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